USA Today's NFL experts make their picks for a Week 1 showdown between the Seattle Seahawks and San Francisco 49ers ...

San Francisco 49ers TE Jake Tonges became the first player in NFL history post-merger to catch a game-winner after recording ...

Watch the best plays from Seattle Seahawks' wide receiver Jaxon Smith-Njigba's 124-yard game against the San Francisco 49ers ...

The San Francisco 49ers, led by quarterback Brock Purdy, face the Seattle Seahawks , led by quarterback Sam Darnold, on ...

San Francisco 49ers head coach Kyle Shanahan talks to the media about whether or not quarterback Brock Purdy will start Week 2 via "NFL Insiders".

NFL Week 1 odds, picks, predictions, TV channel, streaming information for the Sunday football game between San Francisco 49ers and Seattle Seahawks.

George Kittle has been ruled out for the rest of the 49ers' Week 1 matchup with the Seahawks thanks to a hamstring injury.

What TV channel is Arizona Cardinals vs San Francisco 49ers game on? Time, how to watch on television, how to stream NFL Week 3 game Sunday, Sept. 21.

The Seattle Seahawks received a much-needed breakout game from Kenneth Walker III in their Week 2 victory over the Pittsburgh ...

USA Today's NFL experts make their picks for a Week 2 showdown between the New Orleans Saints and San Francisco 49ers ...

NFL Week 3 odds, picks, predictions, TV channel, streaming information for Sunday football game between the Arizona Cardinals and San Francisco 49ers.

The San Francisco 49ers hit the road again in Week 2 of the NFL season to visit the New Orleans Saints. New Orleans is coming off a narrow Week 1 defeat vs. the Arizona Cardinals, while ...