San Francisco 49ers TE Jake Tonges became the first player in NFL history post-merger to catch a game-winner after recording ...

Watch the best plays from Seattle Seahawks' wide receiver Jaxon Smith-Njigba's 124-yard game against the San Francisco 49ers ...

The San Francisco 49ers, led by quarterback Brock Purdy, face the Seattle Seahawks , led by quarterback Sam Darnold, on ...

San Francisco 49ers head coach Kyle Shanahan talks to the media about whether or not quarterback Brock Purdy will start Week 2 via "NFL Insiders".

George Kittle has been ruled out for the rest of the 49ers' Week 1 matchup with the Seahawks thanks to a hamstring injury.

NFL Week 1 odds, picks, predictions, TV channel, streaming information for the Sunday football game between San Francisco 49ers and Seattle Seahawks.

USA Today's NFL experts make their picks for a Week 1 showdown between the Seattle Seahawks and San Francisco 49ers ...

What TV channel is Arizona Cardinals vs San Francisco 49ers game on? Time, how to watch on television, how to stream NFL Week 3 game Sunday, Sept. 21.

USA Today's NFL experts make their picks for a Week 2 showdown between the New Orleans Saints and San Francisco 49ers ...

The Seattle Seahawks received a much-needed breakout game from Kenneth Walker III in their Week 2 victory over the Pittsburgh ...

NFL Week 3 odds, picks, predictions, TV channel, streaming information for Sunday football game between the Arizona Cardinals and San Francisco 49ers.

The San Francisco 49ers hit the road again in Week 2 of the NFL season to visit the New Orleans Saints. New Orleans is coming off a narrow Week 1 defeat vs. the Arizona Cardinals, while ...