The problem of minimizing a concave function subject to linear inequality constraints may have many local solutions. Therefore, finding the global constrained minimum is a computationally difficult ...

This finding indicates an important regulatory role for the MHD motif in the control of R protein activity. To explain these observations, a three-dimensional model of the NB-ARC domain of 1-2 was ...

We show that the Rad50 hook domain is a critical determinant of this function by enabling the dimerization of chromatin-associated monomeric Mre11 complexes.