To explain these observations, a three-dimensional model of the NB-ARC domain of 1-2 was built, based on the APAF-1 template structure. The model was used to identify residues important for 1-2 ...

However, such functional leaps by combination of unrelated domains have not been directly demonstrated. Here we show that highly specific and complex protein functions can be generated by joining a ...

Notably, the isolated V3 domain of PKC-θ acted as a decoy in blocking PKC-θ-dependent functions, including T H 2 and T H 17 differentiation, but not T H 1 differentiation, and inflammation.

A novel biotin-dependent carboxylase with a preference for long-chain acyl-CoA substrates and a unique holoenzyme architecture is described.