If you can't delete an ISO file as the file is open in your System, check if it is mounted as a drive or not. Uses these proven fixes to resolve the issue.

If you cannot delete a file or a folder on an NTFS file system volume in Windows, follow the solutions mentioned in this post to resolve the issue.

If delete doesn't work, try renaming through cmd, then delete. To get Windows Explorer back you can hit ctrl+shift+esc for task manager > file > Run > type explorer > enter.

Time Machine no longer lets you delete individual files from backup snapshots, though you can still delete an entire snapshot. That shouldn’t be a problem: in almost no case does it make sense ...

I am in the process of cleaning up my hard drives. I'm having a problem deleting a file in my old Temp. Internet Files folder from a previous Windows installation.The file is called TILE\\1~1,JPG ...