Global understanding of complement has shifted and developed since the 21st century: from our idea of a blood-based antibiotic system to a global regulator of immunity and tissue homeostasis. Recent ...

Continued activation of complement system damages tissue and blood cells The researchers followed 113 COVID-19 patients for up to one year after their acute SARS-CoV-2 infection and compared them with ...

Researchers discovered a previously unknown mechanism that may drive tissue damage and a new target for drug discovery. Our immune system is armed with an array of defenses designed to detect and ...

Most people infected with the SARS-CoV-2 virus recover after the acute illness. However, a significant proportion of infected individuals develop long-lasting symptoms with a wide range of ...

We are studying the role of the complement system in kidneys and brains during health and disease. Traditionally, major complement proteins were shown to be generated by the liver and are functional ...

New study uncovers how antibody combinations synergistically boost complement activation to combat drug-resistant Klebsiella ...

We read with great interest the recent study by Gilliam-Vigh et al demonstrating significant transcriptomic alterations in ...