After a contentious week, the Tigers can afford another blip. But they have to deal with a dangerous Orange team. Clemson vs Syracuse preview, prediction, and betting lines.

The Syracuse Orange (2-1, 0-0) play their first ACC game of 2025 tomorrow when they head to South Carolina to face the Clemson Tigers (1-2, 0-1). Kickoff is Noon on ESPN and here are our predictions:

Our expert college football predictions expect Syracuse to battle hard enough to cover the spread in their ACC matchup with the Clemson Tigers!

Clemson is currently given a 5.6 percent chance to win the ACC in ESPN's metrics, down from 12.8 percent last week. The Tigers entered the season with a 30.5 percent chance of winning the league championship according to ESPN's FPI.

The Syracuse Orange are 2-1 so far in the 2025 season, but they lost their only matchup with a ranked opponent – Tennessee – in Week 1. They were expecting to f

Syracuse University students are excited and hopeful for Saturday's matchup against Clemson University, despite the Tigers' 1-2 record and the uncertainty of the Orange's performance.

Last year when Syracuse beat Miami, Fran Brown had a message for Dabo Swinney, who got into the ACC Championship Game as a result of the Orange’s comeback win. Fran even followed up his television comments with a call to Dabo later that night and Dabo shouted Fran out after Clemson won the ACC Championship and clinched a CFP berth.

In its last chance to address any growing pains ahead of conference play, Syracuse stormed past Colgate 66-24 Friday night. Here are three key takeaways from the victory. Syracuse